Truly quantitative dietary studies have stringent requirements

Stringent control and growth-rate-dependent control have nonidentical promoter sequence requirements.

Escherichia coli uses at least two regulatory systems, stringent control and growth-rate-dependent control, to adjust rRNA output to amino acid availability and the steady-state growth rate, respectively. We examined transcription from rrnB P1 promoters containing or lacking the cis-acting UP element and FIS protein binding sites after amino acid starvation. The "core promoter" responds to amin...

Stringent sequence requirements for the formation of human telomeres.

In human cells, transfection of telomeric T2AG3 repeats induces the formation of functional telomeres at previously interstitial sites. We report that telomere formation has stringent sequence requirements. While (T2AG3)n telomere seeds formed telomeres in approximately 70% of the transfected cells, five T2AG3-related heterologous telomeric DNAs seeded new telomeres in < 5% of the transfectants...

Prepare now for more stringent joint replacement documentation requirements.

minimal requirements in reporting of qualitative and quantitative studies: critics on two papers

in reply to: minimal requirements in reporting qualitative and quantitative studies: critics on two papers